[Xcelium][xrun] Simulate with multiple builds

I want to do a 2-step build->simulate as follow:

1. Make multiple builds using xrun -elaborate [other options]. The purpose is to create multiple builds with different compile-time macros (+define+MACROA +define+MACROB=ABC). Each build is located in a different directory.

2. Run simulation with xrun -r. This is where I need help. How do I specify which build to simulate? Also, I need the simulation directory (with log files, …) to be different than the build directory.

Has anyone been able to achieve this or similar solutions?